RIPC and Platelet Activation on Platelet Activation During Cardiopulmonary Bypass

Seoul National University Hospital58 enrolled

Overview

In this study, the investigators are going to investigate the effects of remote ischemic preconditioning on platelet activation in patients undergoing cardiac surgery with cardiopulmonary bypass.

Previous studies reported that remote ischemic conditioning reduce platelet activation in patients with coronary artery disease or patients undergoing ablation for atrial fibrillation. Cardiac surgery with cardiopulmonary bypass has been associated with platelet activation. In this randomized study, investigators are going to compare the effects of remote ischemic preconditioning (RIPC) on platelet activation using flow cytometry in patients undergoing cardiac surgery with cardiopulmonary bypass.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Platelet Dysfunction

Interventions

Remote ischemic preconditioningDEVICE

Four cycles of 5 min of ischemia, which is induced by a blood pressure cuff in the upper arm inflated to 200 mmHg, followed by 5 min of reperfusion, during which the cuff is deflated.

Sham controlDEVICE

The same blood pressure cuff is placed around the upper arm, but the cuff is inflated to 10 mm Hg and ischemic preconditioning is not induced.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing cardiac surgery with cardiopulmonary bypass Exclusion Criteria: * Preoperative left ventricle ejection fraction \< 30%, mechanical ventricular support * Peripheral vascular disease * Poorly controlled diabetes mellitus * NSAIDs within 3 days * iv heparin within 6 h * low molecular weight heparin within 24 h * platelet inhibitor within 24 h * known thrombocytopenia * End stage renal disease / hemodialysis * Active infection * Pregnancy

Locations (1)

Seoul National University Hospital

Seoul, South Korea