Berry Components and Blood Sugar & Fat Metabolism

USDA Beltsville Human Nutrition Research Center36 enrolled

Overview

The primary objective of this study is to determine which components of berries improve glucose metabolism and increase fat oxidation in humans.

The aim of this study is to improve understanding of how diet can regulate glucose metabolism and fuel use. Previous human and animal studies have demonstrated that berries can improve gluco-regulation and increase fat oxidation. The aim of this study is to determine which component of berries is conveying this health benefit.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Healthy Volunteers

Interventions

Mixed Berry DietOTHER

Mixed Berry Treatment

Carbohydrate Control JelloOTHER

Carbohydrate Control

Fiber Enriched JelloOTHER

Fiber Control

Low Fiber Mixed Berry Juice

Eligibility

Sex: ALLMin age: 21 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy non-smoker * able to understand consent Exclusion Criteria: * Body Mass Index less than 25 kg/m2 * pregnant, lactating, having given birth in the past year * allergy to berries * blood glucose greater than 125 mg/dL * history of bariatric surgery or nutrient malabsorption disease * diagnosis or treatment of cancer in past three years * type 2 diabetes requiring the use of diabetes pills, insulin, or non-insulin shots

Locations (1)

USDA-ARS Beltsville Human Nutrition Research Center

Beltsville, Maryland, United States

Outcomes

Primary Outcomes

Glucose Metabolism Phase 1

Subjects will undergo a meal-based glucose tolerance test; blood samples will be analyzed for glucose in mmol/L.

Time frame: Day 8

Glucose Metabolism Phase 2

Subjects will undergo a meal-based glucose tolerance test; blood samples will be analyzed for glucose in mmol/L.

Time frame: Day 29

Glucose Metabolism Phase 3

Subjects will undergo a meal-based glucose tolerance test; blood samples will be analyzed for glucose in mmol/L.

Time frame: Day 50

Glucose Metabolism Phase 4

Subjects will undergo a meal-based glucose tolerance test; blood samples will be analyzed for glucose in mmol/L.

Time frame: Day 71

Secondary Outcomes

Insulin sensitivity

Subjects will undergo a meal-based glucose tolerance test; blood samples will be analyzed for insulin in units of microIU/mL.

Time frame: Day 8, 29, 50, 71

Fat trafficking

Subjects will undergo a meal-based glucose tolerance test; blood samples will be analyzed for non-esterified fatty acids in mmol/L.

Time frame: Day 8, 29, 50, 71

Peripheral mononuclear blood cells energetics

Blood cells called peripheral mononuclear blood cells will be isolated and analyzed for mitochondrial function/oxygen consumption in nmol/ml.

Time frame: Day 8, 29, 50, 71

Data from ClinicalTrials.gov

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