Quantitative MRI for Patients With Sickle Cell Disease Undergoing Hematopoietic Cell Transplant

University of Michigan7 enrolled

Overview

The primary purpose of this research is to determine if it is feasible to perform serial magnetic resonance imaging (MRI) to evaluate the amount of bone marrow cells (also called cellularity) and iron stores before and after bone marrow transplantation for severe sickle cell disease.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Sickle Cell Disease

Interventions

serial functional magnetic resonance imaging (MRI)DIAGNOSTIC_TEST

All subjects with sickle cell disease undergoing bone marrow transplantation will undergo up to 4 functional MRI scans.

Eligibility

Sex: ALLMin age: 5 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 5 years. * Diagnosis of SCD (\[Hemoglobin SS (Hb-SS), Hemoglobin SC (Hb-SC) or Hemoglobin S-Beta thalassemia (Hb-Sβ) genotype\]. * Patient is a candidate for an allogeneic HCT. * Subject or guardians have given informed consent. Exclusion Criteria * The need for general anesthesia for MRI. * Subjects with implanted magnetic devices (e.g. pacemakers) that may malfunction or move in the strong magnetic field. * A subject who is pregnant. * Previous HCT.

Locations (1)

University of Michigan

Ann Arbor, Michigan, United States

Outcomes

Primary Outcomes

Feasibility of obtaining serial scans in patients with sickle cell undergoing marrow transplant

Feasibility will be measured by the number of subjects who undergo at least 2 of 4 scheduled functional MRI's

Time frame: 110 days post transplant

Secondary Outcomes

MRI and hemoglobin S.

Correlation between functional MRI result and hemoglobin S level.

Time frame: 1 year post transplant

MRI and neutrophil engraftment

Correlation between functional MRI result and time to neutrophil engraftment

Time frame: 1 year post transplant

MRI and chimerism

Correlation between functional MRI result and time to donor/ recipient chimerism

Time frame: 1 year post transplant

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.