Ocular Findings in Women With Primary Antiphospholipid Syndrome

Cairo University50 enrolled

Overview

Antiphospholipid antibody syndrome (APS) is an autoimmune disease characterized by systemic thrombosis and bad obstetric history. APS secondary to another medical disorder is the most common. Visual and ocular changes e.g. vaso-occlusive disease of retinal and choroidal vessels are found in patients with secondary APS. Patients with primary APS have also been reported to have ocular changes e.g. retinal vascular occlusion The aim of our study to detect prevalence of ocular changes in women diagnosed with primary APS and correlation of these changes with adverse obstetric outcome. If a correlation is present, ocular findings in women with APS could be used in the future as a predictor for poor obstetric outcome.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Primary Antiphospholipid Syndrome

Interventions

Ophthalmological examinationDIAGNOSTIC_TEST

Detailed anterior segment examination using slit-lamp biomicroscopy for signs of anterior uveitis, and detailed fundus examination using slit-lamp fundus biomicroscopy with + 90 diopter lens searching for signs of vasculitis and posterior uveitis.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age: 18 to 35 years * Females with primary antiphospholipid syndrome Exclusion Criteria: * Age: below 18 years and above 35 years * Auto-immune diseases e.g. SLE and other connective tissue disease * Medical diseases causing retinal vascular changes e.g. hypertension, diabetes mellitus, sickle cell anemia. * Previous vitreo-retinal surgery

Outcomes

Primary Outcomes

The incidence of Ocular changes in females with antiphospholipid syndrome

Number of participants with ocular findings detected by ophthalmological examination

Time frame: On the same day of enrollment into the study