Effect of Turner Syndrome on Number Sense

Stanford University

Overview

This study evaluates approximate number sense (ANS) in children, adolescents, and adult women with Turner syndrome compared to age-matched healthy peers. One primary aim of this project is to assess the effectiveness of an online ANS training tool in enhancing complex mathematics ability. Participants will undergo weekly training sessions in their own home. Half of the participants will complete 2 training sessions a week for 8 weeks, and the second half will complete 1 training session for 8 weeks.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Conditions

Turner Syndrome

Interventions

ANS trainingBEHAVIORAL

In-home computer-based ANS training

Eligibility

Sex: FEMALEMin age: 6 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Children, adolescents, and adult women with Turner syndrome. * Healthy controls. * Normal or corrected to normal vision. Exclusion Criteria: * Major psychiatric or developmental disorder (e.g., bipolar disorder, major depression, psychotic disorders, intellectual disability, autism spectrum disorder). * Chemical dependency * Currently taking the following medications: antidepressant, antipsychotic, and anti-seizures drugs.

Locations (1)

Center for Interdisciplinary Brain Sciences Research

Stanford, California, United States

Outcomes

Primary Outcomes

Single and multiple-operand addition and subtraction accuracy

Task accuracy calculated as the percentage of trials answered correctly.

Time frame: 8 weeks

Single and multiple-operand addition and subtraction response time

Average amount of time, in seconds, required to answer each question on the task.

Time frame: 8 weeks

Data from ClinicalTrials.gov

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