The main purpose of the CoDISEN cohort study is to propose a model of prevention and care for HIV and viral hepatitis adapted to the needs of people who inject drugs (PWID) in Dakar, Senegal.
THE UNODC estimated the number of consumers of injectable drugs at 1,02 millions in 2012 in Africa among which 12,1 % lived with HIV. Prevalences of HIV, chronic hepatitis C and B among people who inject drugs remain little documented in Sub-Saharan Africa. The transmission of HCV in Africa is mainly hospital-borne, bound to a precarious transfusional and therapeutic safety. However, the transmission by intravenous drug use emerges as a new stake in public health in urban areas. The report of a strong HIV prevalence in the population of PWID in the sub-region ( for example, In 2007, in the Cape Verde, prevalence of the HIV was 14 % in emprisoned PWID against 0,8 % in the general population) contributed to assert the reality of the use of intravenous drugs in the region and the vulnerability of this population. Senegal, a country with an concentrated HIV epidemic \[0,5 % prevalence in 2012, WHO source\] is the first country of western Africa to have measured prevalence of HIV (5,2 %), HBV (7,9 %) and HCV (23,3 %) in PWID (Study ANRS 12243). In view of these results, the Senegalese authorities introduced from October, 2011 in Dakar, activities of harm reduction by means of a mobile team of social workers and mediators allowing individual and collective activities of prevention, needle exchange program, references for care and follow-up, as well as a opioid substitution program in a methadone center (CEPIAD) located in Dakar, first of its kind in Western Africa. The objective of the present research project thus is to estimate the impact of a strategy of " test and treat " of HIV and harm reduction initiatives on the prevalence and incidence of HIV, HBV and HCV infections in an population of injectable drug consumers followed in the methadone center ( CEPIAD) of Dakar, Senegal
Study Type
OBSERVATIONAL
Enrollment
208
CEPIAD
Dakar, Senegal
incidence of HIV
number of participants infected with HIV at inclusion and acquiring HIV during follow-up
Time frame: 24 months
incidence of hepatitis C infection (HCV)
number of participants infected with HCV at inclusion and acquiring HCV during follow-up
Time frame: 24 months
incidence of hepatitis B infection (HBV)
number of participants infected with HBV at inclusion and acquiring HBV during follow-up
Time frame: 24 months
incidence of relevant coinfections and comorbidities
number of patients developping sexually transmitted infections, tuberculosis and other conditions -% Test realized / test planned
Time frame: 24 months
Retention rate and its determinants
Number of participants retained in the cohort follow-up + analysis of determinants of retention
Time frame: 24 months
mortality rate and determinants
Number of participants dead during follow-up + analysis of determinants of death * evolution of CD4 and HIV viral load in participants with HIV and treated with ARVs, HBV viral load , and HCV viral load in participants with viral hepatitis B and C * Incidence of clinical events and biological of interest
Time frame: 24 months
Access to treatment of HCV, HBV infections and other coditions requiring specific therapeutical management
Number of patients treated for HIV, HBV, HCV and other medical conditions according to national or international guidelines recommendations
Time frame: 24 months
Effectiveness of tuberculosis regimens
Number of cured patients / number of patients initiating treatment
Time frame: 24 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.