Improving REsectability in Pancreatic NEoplasms (IRENE)

Inclusion Criteria: * histological diagnosis of locally advanced pancreatic carcinoma, not upfront surgically treated (according to NCCN resectability criteria), without distant metastases * NCCN criteria resectability status * patient's age, performance status, possible presence of comorbidity should also be considered to decide the optimal approach (upfront surgery versus neoadjuvant treatment). * If the chemotherapy treatment induces the disease to a condition of resectability, the patient will undergo a surgical evaluation * indication for radiotherapy treatment * ECOG 0-2 * obtaining informed consent * not pregnant or breastfeeding Exclusion Criteria: * ECOG\> 2 * presence of internal diseases for which radiotherapy is contraindicated, or diseases of the connective system, or gastric or duodenal ulcer in progress or acute diverticulitis, ulcerative colitis * comorbidity which in the opinion of the referring physician may constitute a risk for participation in the study * lack of availability for clinical-instrumental follow-up * previous abdominal radiotherapy.