The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone monoester, is proposed to have glucose-lowering potential but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone monoester can improve the glycemic response to an oral glucose tolerance test in individuals with impaired fasting glucose.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
15
Acute ingestion of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate prior a 2-hour oral glucose tolerance test.
Acute ingestion of a taste-matched placebo prior a 2-hour oral glucose tolerance test.
University of British Columbia, Okanagan.
Kelowna, British Columbia, Canada
Glucose area under the curve
Area under the curve for glucose during oral glucose tolerance test
Time frame: 2-hour
Insulin area under the curve
Insulin area under the curve during oral glucose tolerance test
Time frame: 2-hour
Free fatty acids area under the curve
Non-esterified fatty acids area under the curve during oral glucose tolerance test
Time frame: 2-hour
Caspase-1 activation
Caspase-1 activation assessed before and after ketone or placebo ingestion in the morning
Time frame: 15 minutes
Inflammatory cytokines
Inflammatory cytokines assessed before and after ketone or placebo ingestion in the morning
Time frame: 15 minutes
C-peptide area under the curve
C-peptide area under the curve during oral glucose tolerance test
Time frame: 2-hour
GLP-1 area under the curve
GLP-1 area under the curve during oral glucose tolerance test
Time frame: 2-hour
Glucagon area under the curve
Glucagon area under the curve during oral glucose tolerance test
Time frame: 2-hour
Glucose incremental area under the curve
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Incremental area under the curve (above baseline) for glucose during oral glucose tolerance test
Time frame: 2-hour
Insulin incremental area under the curve
Incremental area under the curve (above baseline) for insulin during oral glucose tolerance test
Time frame: 2-hour
2-hr glucose level
Plasma glucose assessed 2-hr after oral glucose tolerance test.
Time frame: 2-hour
Oral glucose sensitivity index
Oral glucose sensitivity index derived from glucose and insulin values throughout the 2-hr oral glucose tolerance test
Time frame: 2-hour