A prospective randomized study included 210 women with Unexplained infertility subjected to combined ovarian stimulation and Intrauterine insemination (IUI). Two equal groups. Study group, subjected to uterine flushing with Human chorionic gonadotropin (HCG) one day before IUI and control group subjected to IUI alone.
A prospective randomized study included 210 patients with Unexplained infertility subjected to coupled ovarian stimulation and Intrauterine insemination (IUI). Two equal groups. Study group, subjected to uterine flushing with Human chorionic gonadotropin (HCG) one day before IUI and control group subjected to IUI alone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
210
HCG Uterine flushing was done one day before IUI with HCG (500 IU) in 10 ml of saline.
Intrauterine insemination (IUI)
Flushing of the vagina with 10 ml of saline
Live birth
Defined as pregnancies maintained beyond 20 weeks of gestation
Time frame: 10 months of randomization
Chemical pregnancy
Defined as positive serum pregnancy test
Time frame: One month after randomization
Clinical pregnancy
Defined by the presence of gestational sac with fetal heartbeats on ultrasound scan or histological identification of trophoblastic tissue.
Time frame: Two months after randomization
Adverse effects
Nausea, vomiting, and pain
Time frame: one hour of the procedure
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