To test the efficacy of different vitamin D delivery methods on serum 25(OH)D. Participants randomly assigned to one of seven groups - three placebo groups and 4 active supplement groups receiving 100,000IU vitamin D3
Various delivery methods of vitamin D supplementation are available to consumers but there have been no studies providing evidence of whether one delivery method is superior to others. The researchers wanted to compare the delivery of 100,000IU vitamin D3 by three methods on serum 25(OH)D levels. Two methods of oral supplementation (pill \[prolonged release\] and liquid \[immediate release\]), and delivery through the skin (with and without a penetrator enhancer. Placebo groups were pill, oral liquid and skin applied oil
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
62
100,000IU
Dicalcium phosphate, microcrystalline cellulose, silicium dioxide, magnesium stearate
100 drops orange syrup
University of Wolverhampton
Walsall, West Midlands, United Kingdom
serum 25(OH)D
Changes in serum 25(OH)D levels
Time frame: 4 weeks
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Paraffinum Liquidum,Isopropyl Palmitate,Parfum
Tangerine essential oil (10ml)