Brain Oxygenation During Cardiopulmonary Resuscitation

Helsinki University Central Hospital80 enrolled

Overview

The study is aimed to assess (a) the incidence of hyperoxia at the point of return of spontaneous circulation (ROSC) and (b) the role of arterial blood oxygen partial pressure to brain oxygenation during out-of-hospital cardiac arrest. 80 adult patients will be recruited in a physician staffed helicopter emergency medical services. Brain regional oxygen saturation and invasive blood pressure are monitored until hospital admission and arterial blood gases are analyzed immediately when the unit arrives to the patient and again at the time of ROSC.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiac Arrest, Out-Of-Hospital

Interventions

Standard cardiopulmonary resuscitationOTHER

Standard Advanced Life Support based on guidelines 2015, including mechanical chest compression device

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * out-of-hospital cardiac arrest of presumed cardiac origin * resuscitation will be continued at least 5 minutes (if return of spontaneous circulation not achieved earlier) after arrival of physician team Exclusion Criteria: * do-not-attempt-resuscitation (DNAR) order or withdrawal of treatment by prehospital critical care physician * return of spontaneous circulation achieved before physician-led critical team arrives * external cause for cardiac arrest (e.g. trauma, suffocation) * workload too high or environment too dangerous to perform study procedures

Locations (1)

FinnHEMS 10, Emergency Medicine and Services, Helsinki University Hospital

Vantaa, Finland

Outcomes

Primary Outcomes

Arterial oxygen partial pressure

Arterial oxygen partial pressure at the time of return of spontaneous circulation (ROSC)

Time frame: 5-60 minutes

Secondary Outcomes

Forehead regional oxygen saturation during resuscitation

Oxygen saturation measured using near-infrared spectroscopy

Time frame: 0-60 minutes

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.