Influence of Respiratory Gases Conditioning on Aerosol Delivery During Invasive Ventilation

Cliniques universitaires Saint-Luc- Université Catholique de Louvain34 enrolled

Overview

The intention is to enroll a specific sample of intubated patients. To compare the effect of respiratory gas conditioning on lung deposition and considering the well-known influences of lung pathology on lung deposition, intubated patients with healthy lungs will be included. Postoperative neurosurgery ventilated patients respond perfectly to this criteria. A previous study including 17 postoperative neurosurgery patients was performed in 2013 with a perfect collaboration between the ICU and the Department of Neurosurgery and Anesthesiology.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Brain Injuries, Traumatic

Interventions

Aerogen Solo®

Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation

Heated-humidified circuitDEVICE

It will be left on during the transfer and the nebulization in group 1

Heated-humidified circuitDEVICE

It will be turned off 30 minutes before the nebulization (nebulization ended max 45 minutes after turning off the heated-humidifier).

Dry ventilator circuit specific for aerosol therapyDEVICE

Streamlined components, specific position for the nebulizer at 30 cm of a V-shaped Y piece

Conventional dry ventilator circuit with HME filterDEVICE

The nebulizer is placed between the filter and the endotracheal tube.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18 years or older * Postoperative neurosurgery intubated patients admitted for brain neurosurgery in the ICU (Intensive care neuro-traumatologic and Toxicologic)- With a healthy lung function. * Signed and dated informed consent should be obtained in accordance of local regulations. Exclusion Criteria: * Spine neurosurgery * History of cardiovascular and pulmonary disease * Extubation immediately after surgery * Modification of the allocated humidification technique before or during the nebulization (heated-humidifier deficiency or safety concern) * Inaccurate quantification of aerosol deposition (i.e., artifacts or overlap of tracheal and pulmonary deposition).

Locations (1)

Cliniques Universiataires Saint-Luc

Brussels, Belgium

Outcomes

Primary Outcomes

Quantity of aerosol deposition from the nebulizer reservoir to the subject. Measured by Planar scintigraphy.

% of the nominal dose.

Time frame: 45 minutes

Data from ClinicalTrials.gov

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