Safety Study of LLF580 in Obese Volunteers

Inclusion Criteria: * Body mass index (BMI) within the range of 30 to 45 kg/m2, inclusive, with ethnic adjustment (≥27.5 kg/m2 for Asian individuals). * Fasting triglyceride 150 - 500 mg/dL (1.69 - 5.65 mmol/L), inclusive, at screening. * Able to communicate well with the investigator, to understand and comply with the requirements of the study. Exclusion Criteria: * History of hepatobilliary disease. * Liver disease or liver injury as indicated by abnormal liver function tests. * Chronic infection with Human Immunodeficiency Virus (HIV), Hepatitis B (HBV) or Hepatitis C (HCV). * Fasting triglycerides greater than or equal to 500 mg/dL \[5.65 mmol/L\], or concomitant use of drug treatment for hypertriglyceridemia (fibrates, omega-3 fatty acids, nicotinic acid). * History of pancreatic injury or pancreatitis. * History of hypersensitivity to drugs of similar biological class, FGF21 protein analogue, or Fc fusion proteins. * History of bone disorders or low vitamin D level. * Contraindications to MRI. * Change in body weight (more than 5% self-reported OR 5 kg self-reported change during the previous 3 months). * Use of weight loss drugs. * Enrollment in a diet, weight loss or exercise programs.