Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics

University of Nevada, Reno104 enrolled

Overview

This study will assess the efficacy of oral vancomycin prophylaxis in preventing recurrent Clostridium difficile infection in hospitalized patients requiring oral or intravenous antibiotics for a suspected or confirmed bacterial infection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

104

Conditions

Clostridium Difficile Infection

Interventions

Oral VancomycinDRUG

Oral vancomycin will be given concurrently with antibiotics to hospitalized patients with a history of Clostridium difficile infection to prevent recurrence

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age ≥18 years 2. Previous CDI diagnosis 3. Current admission with a suspected or a confirmed bacterial infection requiring antibiotics Exclusion Criteria: 1. Active chronic diarrheal illness (eg, Crohn's disease, ulcerative colitis, short bowel syndrome) 2. Previous adverse reactions to oral vancomycin 3. Requiring metronidazole during hospitalization 4. Known pregnancy 5. Expected survival \<72 hours 6. Patients receiving antibiotics only for surgical prophylaxis 7. Patients who received prophylactic oral vancomycin for the current antibiotic course prior to enrollment in the study

Locations (1)

Renown Regional Medical Center

Reno, Nevada, United States

Outcomes

Primary Outcomes

Recurrent Clostridium difficile infection

Diarrheal illness, with at least 3 episodes of watery diarrhea over a 24 hour period and a positive toxin analysis or a positive PCR for Cdiff