The Effectiveness of Vancomycin in Comarison With Cefazolin in Prevention of SSI After Craniotomy

Isfahan University of Medical Sciences126 enrolled

Overview

Surgical-site infection is the most commonly reported nosocomial infection in patients undergoing surgery and 3rd most nosocomial infection in hospitalized patients. The SSI is associated with increases of length of hospitalization for 6 days and increases the hospital's cost by $ 300. Because of these, prevention of SSI with appropriate antibiotic is essential.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

126

Conditions

Elective Craniotomy-candidated Patients

Interventions

VancomycinDRUG

The 1st group receives vancomycin an hour before craniotomy

CefazolinDRUG

The 2nd group receives cefazolin an hour before craniotomy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age 18 years and above * elective surgical patients * No pre-surgery infection * Do not use antibiotics before surgery * Insensitivity to beta-lactam antibiotics Exclusion Criteria: * cranioplasty * Failure to follow the patient * The patient's unwillingness to continue participating in the research project * Death of the patient

Locations (1)

Isfahan university of medical science.

Isfahan, Iran

Outcomes

Primary Outcomes

infection rate

compare of infection rate in 2 groups

Time frame: Until 90 days after admission

Secondary Outcomes

length of hospitalization

compare the length of hospitalization in 2 groups

Time frame: Until 90 days after admission

raise of ESR & CRP

compare the raise of ESR \& CRP in 2 groups

Time frame: Until 90 days after admission

Central Contacts

Rasool Mohammadi, Student

CONTACT

+989365725957 rasool.mohammadi1993@yahoo.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.