This study uses an experimental design to conduct a double-blind, randomized, crossover study where participants receive both diesel exhaust and a mental stress test in a controlled setting. My hypothesis is that the synergistic effect of stress and air pollution will result in higher levels of stress and inflammation (measured via biological markers) as well as poorer cardiovascular disease related outcomes compared to the independent effect of each exposure separately.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
22
Subjects are asked to give a 5 minute speech on a topic selected by the investigator. Then they are asked to subtract 7 from 758.
Diesel exhaust is an air pollutant found in the environment and produced by cars, trucks and other transportation modes (e.g. trains, planes).
University of Washington Diesel Exhaust Facility
Seattle, Washington, United States
RECRUITINGChange in norepinephrine
Urinary norepinephrine in ng/mg
Time frame: Change in norepinephrine from baseline (pre-exposure) to immediately after exposure
Change in epinephrine
Urinary epinephrine in ng/mg
Time frame: Change in epinephrine from baseline (pre-exposure) to immediately after exposure
Change in dopamine
Urinary dopamine in ng/mg
Time frame: Change in dopamine from baseline (pre-exposure) to immediately after exposure
Change in d-dimer
plasma d-dimer (ug/ml) is a measure of coagulation
Time frame: change in d-dimer from baseline (pre-exposure) to six hours post exposure
Change in fibrinogen
plasma fibrinogen (mg/dl) is a measure of coagulation
Time frame: change in fibrinogen from baseline (pre-exposure) to six hours post exposure
Change in interleukin-6 (IL-6)
plasma IL-6, measured in pg/ml, is a marker of inflammation
Time frame: change in IL-6 from baseline (pre-exposure) to immediately after exposure
Change in tumor necrosis factor alpha (TNF-a)
plasma TNF-a, measured in pg/ml, is a marker of inflammation
Time frame: change in TNF-a from baseline (pre-exposure) to immediately after exposure
Change in interleukin-1b (IL-1b)
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plasma IL-1b, measured in pg/ml, is a marker of inflammation
Time frame: change in IL-1b from baseline (pre-exposure) to immediately after exposure