Therapeutic Effects of Endoscopic Ablation of Hunner Lesions in Interstitial Cystitis/ Bladder Pain Syndrome Patients

Samsung Medical Center442 enrolled

Overview

efficacy of endoscopic ablation of Hunner lesions in patients with IC/BPS and the characteristics of HLs based on a long-term follow-up

Study Type

OBSERVATIONAL

Enrollment

442

Conditions

Interstitial Cystitis

Interventions

Transurethral ablationPROCEDURE

transurethral resection and/or coagulation with a bipolar loop under spinal or general anesthesia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Male and female aged 18 yrs or greater 2. Patients diagnosed with BPS(Bladder Pain Syndrome) 3. Symptom persisted more than 6 months 4. Pain VAS ≥4 5. O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q) scores 12 or greater with pain and nocturia domain scores \> 2. 6. Pelvic Pain and Urgency/Frequency Patient Symptom Scale(PUF) \>13 7. No history of cystoscopy within 2yrs. Exclusion Criteria: 1. History of augmentation cystoplasty or previous transurethral coagulation/resection due to BPS 2. Child-bearing potential, pregnant or nursing women. 3. Mean voided volume lesser than 40ml or over than 400ml. 4. Hematuria exceeds 1+ in the urinary dipstick (dipstick) examination. 5. Urinary tract infection during run-in periods. 6. Genitourinary tuberculosis or bladder,urethral and prostate cancer 7. Recurrent urinary tract infection 8. History of hysterectomy,mid-urethral sling,pelvic organ prolapse repair,vaginal delivery or Cesarean section,prostate operation or treatment etc within 6months. 9. Neurologic disease history of cerebral infarction,multiple sclerosis or parkinsonism etc.-

Locations (1)

Samsung Medical Center, Sungkyunkwan University School of Medicine

Seoul, South Korea