Laparoscopic D2 Distal Gastrectomy Following Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancers

Inclusion Criteria: * First Round Inclusion Criteria 1. Age from over 18 to under 75 years; 2. Primary gastric adenocarcinoma (including pap, tub, muc, sig, and por) confirmed pathologically by endoscopic biopsy; 3. cT3-4a, N-/+, M0 according to the AJCC 8th Cancer Staging Manual; 4. Without peritoneal metastasis (examined by laparoscopic examination); 5. Radical resection (R0) through distal subtotal gastrectomy with D2 lymphadenectomy is anticipated; 6. Performance status 0 or 1 (Eastern Cooperative Oncology Group) ; 7. ASA (American Society of Anesthesiology) score ≤ 3; 8. Normal hemodynamic indices: <!-- --> 1. Blood cell count: HB ≥ 90g/L, ANC ≥ 1.5×109/L, PLT ≥ 80×109/L; 2. Liver and renal function: BIL\<1.5 times of the upper limit of normal reference values, ALT and AST\<2.5 times of the upper limit of normal reference values, and Crea≤1 time of upper limits of normal reference values. * Second Round Inclusion Criteria 1. Therapeutic response rating after neoadjuvant chemotherapy is CR, PR, SD, or Therapeutic response rating after neoadjuvant chemotherapy is PD, tumor is expected to have radical resection; 2. Subjects are still willing to continue participating in this clinical trial. Exclusion Criteria: * First Round Exclusion Criteria 1. History of upper abdominal surgery (include endoscopic mucosal resection or endoscopic submucosal dissection, except for laparoscopic cholecystectomy); 2. History of acute pancreatitis; 3. Enlarged or bulky regional lymph node (diameter\>3cm) by imaging exam; 4. Patients have received neoadjuvant therapy prior to screen work; 5. History of other malignant disease within the past five years; 6. History of cerebrovascular accident within the past six months; 7. History of continuous systematic administration of corticosteroids within the past month; 8. Scheduled simultaneous surgery for other disease; 9. Emergency surgery due to complication (bleeding, obstruction or perforation) caused by gastric cancer; 10. Pyloric obstruction; 11. FEV1\<50% of predicted value; 12. Women who are pregnant or lactating at the time of screening; 13. Severe mental disorder; 14. Participating in other clinical studies; 15. Refused to sign the informed consent; * Second Round Exclusion Criteria 1. Therapeutic response rating after neoadjuvant chemotherapy is PD, involvement of adjacent structures(T4b), distal metastasis(M1), or enlarged or bulky regional lymph node (diameter\>3cm) by preoperative imaging 2. Patients cannot complete 3 cycles of chemotherapy due to intolerance; 3. After 3 cycles of neoadjuvant chemotherapy, patients cannot tolerate surgery due to severe adverse reactions, or ASA score ≥ 4 ; 4. Patients undertake emergency operation due to tumor bleeding, perforation or obstruction during chemotherapy; 5. After signing the informed consent, the patient withdraws from this clinical trial. Withdrawal Criteria After Second Round: 1. Intro-abdominal metastasis of primary cancer is revealed intraoperatively; 2. Primary cancer is confirmed to be un-resectable intraoperatively.