(TIMP-2)x(IGFPB7) to Predict Acute Kidney Injury (AKI) in Aortic Surgery

Jörg Schefold100 enrolled

Overview

New biomarkers that predict the development of renal dysfunction in patients with aortic surgery are urgently needed. The investigators investigate whether urinary (TIMP-2)x(IGFBP7) predicts postoperative Acute Kidney Injury and/or need for Renal Replacement Therapy (RRT) in patients after aortic surgery (including EVAR).

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Renal Failure Dialysis Aortic Surgery Biomarker Acute Kidney Injury

Interventions

does not applyOTHER

biological sample taking: urine, blood

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients in need of emergency or elective abdominal aortic surgery (infra- or suprarenal clamping or EVAR) are eligible for study inclusion. Exclusion Criteria: * Patients unable to give informed consent * Age \< 18 * Patients not speaking German or French.

Locations (1)

Inselspital

Bern, Switzerland

Outcomes

Primary Outcomes

Statistically significant difference in mean total (TIMP-2)x(IGFBP7) values of patients with/ without AKI (as defined along Kidney Disease Initiative for Improvement of global outcomes (KDIGO) definitions: stages 1-3) at the first postoperative day.

Time frame: 24 hours following ICU admission

Data from ClinicalTrials.gov

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