Predictive Factors for Failure or Success of Endoscopic Treatment of Superficial Colorectal Tumors

Institut Paoli-Calmettes100 enrolled

Overview

To evaluate the long-term complete remission rate (\> 12 months) after endoscopic treatment of early neoplastic colorectal lesions.

Intra-mucous colorectal neoplasia lesions (or even with minimal mucosal infiltration), formerly treated surgically, are increasingly treated endoscopically. The IPC as a center for interventional endoscopy has been taking care of these lesions for several years. Resection techniques have diversified since the 2000s (polypectomy, monobloc or piecemeal mucosectomy, submucosal dissection ... etc) and the endoscopy team has developed its various techniques within the institute ; Practice has evolved and has not been studied or evaluated in recent years. The purpose of this study is to evaluate practices and to compare results with the literature, and to identify predictive factors for the failure or success of endoscopic treatment of these early neoplastic lesions.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Superficial Colorectal Tumors

Interventions

Evaluation of the long-term complete remission rate (> 12 months)OTHER

Evaluation of the long-term complete remission rate (\> 12 months)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient having undergone endoscopic resection of a colorectal lesion stage 4 or 5 of the modified Vienna classification during the last 5 years at the institute. Exclusion Criteria: * Adenomas with low grade dysplasia * Endoscopic control not available

Locations (1)

Institut Paoli Calmettes

Marseille, Bouches Du Rhone, France

Outcomes

Primary Outcomes

Complete long-term remission (> 12 months)

Evaluation of the long-term complete remission rate (\> 12 months)

Time frame: 13 months

Secondary Outcomes

Absence of residual lesion on early control (3 to 6 months)

Medium-term response rate (3 to 6 months)

Time frame: 3 to 6 months

Rates of medium and long-term recurrence

Recurrence rate in the medium and long term

Time frame: 13 months

Management of medium and long-term recurrence

Management of recurrence (endoscopic revision or surgery)

Time frame: 13 months

Morbidity and mortality rates

Morbidity and mortality rate of endoscopic resection

Time frame: 13 months

Lymph node or visceral metastatic evolution rate

Rate of pejorative lymph node or metastatic evolution (especially for lesions with microinfiltration of the submucosa)

Time frame: 13 months

Endoscopic description and anatomopathological results

Endoscopic and / or anatomopathological predictive factors of success (complete long-term remission)

Time frame: 1 day

Data from ClinicalTrials.gov

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