PACAP27 Headache Properties in Migraine Without Aura Patients

Inclusion Criteria: * Migraine patients meeting International Headache Society (IHS) criteria for migraine without aura of both sexes, 18-60 year, 50-100 kg. * Fertile women should use safe contraception. Fertile women do not include hysterectomized women or women who are postmenopausal for at least 2 years. Safe contraception includes either Intra Uterine Device (IUD), birth control pills, surgical sterilization of the woman or depot progestogen. Exclusion Criteria: * Tension Type headache for more than 5 days the month on average in the last year. * All other primary headaches . * Headache later than 48 hours before trial start. * Daily intake of any medicine other than oral contraception. * Ingestion of any form of medicinal product later than 4 times the plasma half-life substance (on trial day), except for oral contraception. * Pregnant or breastfeeding women. * Headache on the test day or later than 48 hours prior to administration of trial medicine / placebo * Migraine within 5 days before the trial date. * Ancestral information or clinical signs of (on the day of inclusion): * Hypertension (systolic blood pressure\> 150 mmHg and / or diastolic blood pressure\> 100 mmHg) * Hypotension (systolic blood pressure \<90 mm Hg and / or diastolic blood pressure \<50 mmHg) * Cardiovascular disease of all kinds, including cerebrovascular disease. * Anamnestic or clinical signs of mental illness or abuse. * Patients with glaucoma or prostatic hyperplasia * Anamnestic or clinical signs of diseases of any kind such as the investigating physician is considered relevant for participation in the trial.