A Window of Opportunity Study to Investigate Mechanisms of Actions of Novel Therapeutic Agents in Patients With Resectable Solid Tumor Malignancies

Inclusion Criteria: 1. Must have biopsy-proven solid tumor that is eligible for elective surgical resection, disease does not require immediate therapy, and there is NO approved/ standard therapy available that is shown to prolong overall survival. 2. ECOG performance status of 0 or 1. 3. Must have a tumor lesion that is amenable to biopsy, and willing to undergo biopsy. 4. Willing to provide tissue and blood samples for research. Exclusion Criteria: 1. The following solid tumors are NOT eligible: Primary brain tumor, Ocular melanoma, Head and neck cancer, Breast cancer, Prostate cancer, Testicular cancer, and Stage III rectal cancer. 2. Any active malignancy within 3 years prior, except: Adequately treated basal cell or squamous cell skin cancer, or early stage cancers (carcinoma in situ or stage 1) treated with curative intent. 3. Any uncontrolled intercurrent illness, including but not limited to: Symptomatic congestive heart failure, Unstable angina pectoris or coronary angioplasty or stenting within 6 months prior to enrollment, Cardiac arrhythmia, Psychiatric illness or social situations that would limit compliance with study requirements, or Ongoing or active infection. 4. Any known sensitivity to or history of allergic reaction to compounds of similar chemical or biological composition of study drug(s). 5. Unwilling or unable to follow the study schedule. Other protocol defined inclusion/exclusion criteria may apply.