Study of Intracoronary CD34+ Cell Administration in Patients With Early Coronary Atherosclerosis

Inclusion Criteria: * Diagnosis of coronary endothelial dysfunction based on coronary angiogram and acetylcholine comprehensive coronary physiology study * Able to provide informed written consent and willing to participate in all required study follow-up assessments Exclusion Criteria: * Acute coronary syndrome or continuous/ongoing chest pain - unremitting and unresponsive to nitroglycerin or rest - persisting 4 or more days before stent placement. If the chest pain syndrome is transient and/or intermittent - even if it began more than 3 days prior to admission - the patient is not excluded. * Subjects in cardiogenic shock (systolic pressure \< 80mm/Hg, on vasopressors or intraaortic counter pulsation) at the time of consenting. Subjects who recover from cardiogenic shock by the time of consenting are eligible. * Subjects unable to receive antiplatelet agents (e.g. aspirin, clopidogrel, ticlopidine,prasugrel, etc). * Abnormal laboratory values (Hgb \<11 mg/dL; glomerular filtration rate (GFR)\<50; liver function tests (LFTs)\>2x upper limit of normal). * Subjects receiving warfarin who have an international normalized ratio (INR) \>2 at the end of the screening phase or with major bleeding requiring active transfusion support. * Subjects with severe cardiac valvular disease expected to undergo surgery within 1 year. * Subjects with known severe immunodeficiency states (AIDS). * Significant coronary artery disease on coronary angiogram * Cirrhosis requiring active medical management. * Malignancy requiring active treatment (except basal cell skin cancer). * Subjects with documented active alcohol and /or other substance abuse. * Females of child bearing potential unless a pregnancy test is negative within 7 days of the bone marrow harvest. * Re-occlusion of the infarct related artery (IRA) prior to the infusion procedure. * Planned revascularization intervention during the next 6 months. (A second PCI can be performed if done prior to qualifying cardiovascular magnetic resonance imaging (CMR) at least 96 hours post primary PCI). * Participation in an ongoing investigational trial. * Active or suspected bacterial infection requiring systemic intravenous antibiotics. * Additional factors deemed unsuitable for trial enrollment per discretion of principal investigator * Inmates