The aim of this study is the quantitative determination of bone-specific microRNAs in the serum of postmenopausal women with osteoporosis during antiresorptive or osteoanabolic therapy.
Primarily the influence of the therapeutic treatment on the microRNA concentration in the serum (treatment-response) and the relation between microRNA serum levels and changes of the bone mineral density will be investigated. These data will help to examine the use of microRNAs as novel diagnostic biomarkers for the diagnosis of osteoporosis and targeted therapeutic treatment of patients.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
26
antiresorptive treatment with Prolia
osteoanabolic treatment with Forsteo
Medical University Vienna; St. Vincent Hospital
Vienna, Austria
detection of microRNA concentration in serum
influence of antiresorptive or osteoanabolic Treatment on microRNA levels in postmenopausal women with osteoporosis
Time frame: 24 months
microRNAs and changes in bone metabolism under treatment
correlation of microRNA with bone turnover markers, fracture risk, BMD
Time frame: 24 months
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