This study investigates the influence of dietary nitrate supplementation on cardiovascular health and physical and cognitive performance in older adults. Participants will receive both a nitrate containing beetroot juice for 10 days and a nitrate depleted beetroot juice for 10 days
A recent exciting finding is that dietary nitrate supplementation (in the form of beetroot juice) appears to reduce the amount of oxygen needed to complete moderate intensity walking in healthy, young individuals. Nitrate is known to be converted in the body to nitric oxide (NO), a substance which reduces blood pressure and may affect the energy-producing mechanisms inside muscle cells. Exercise tolerance and muscle function typically declines with age and nitrate supplementation therefore may help improve cardiovascular health and the ability to carry out low-intensity daily activities in aging populations. The purpose of this study is to see if healthy, elderly individuals benefit from beetroot juice intake similarly to the effects seen in young adults. If this is indeed the case, then it may suggest that dietary supplementation with a relatively cheap, widely available, and natural food product may improve the ability of healthy elderly individuals to undergo everyday tasks and ultimately improve their quality of life.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
30
concentrated beetroot juice
concentrated beetroot juice
Sport and Health Sciences, University of Exeter
Exeter, Devon, United Kingdom
Blood pressure
Change in blood pressure between interventions
Time frame: 10 days
Oxygen cost of exercise
Change in oxygen consumption during exercise
Time frame: 10 days
Serial Subtraction test
change in performance of the Serial Subtraction test
Time frame: 10 days
Microbiome
change in oral microbiome measured by sequencing bacterial 16S rRNA genes
Time frame: 10 days
Brain metabolism
change in brain metabolites measured measured by 1H MRS
Time frame: 10 days
6 minute walk test
change in performance of 6 minute walk test
Time frame: 10 days
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