genetic screening and etiological analysis was conducted on patients with ovarian insufficiency and decline in ovarian reserve. All patients were enrolled in the IVF-treated and non-IVF-treated groups, followed up for long-term treatment outcomes and genomic screening.
The cause of ovarian insufficiency and decline in ovarian reserve are not clear, but most researchers think the probable causes are mainly three aspects: chromosomal abnormalities, genetic factors and autoimmune diseases，But the majority of patients with normal chromosome karyotype analysis. The screening of pathogenic genes in patients with normal karyotype is the focus of current premature ovarian insufficiency(POI) and decline in ovarian reserve(DOR) etiology, to further explain the pathogenesis of patients, improve the diagnosis of those diseases and Clinical treatment.
Study Type
OBSERVATIONAL
Enrollment
300
Relationship between IVF treatment outcome and genotypes in POI//DOR/ovarian dysgenesis patients
Reproductive Medicine Center, the First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China
RECRUITINGGenotype
Measure the genotype by genome-wide sequencing of exomes(WES) in subjects.
Time frame: 1/4/2018-24/12/2020
Dimensions of uterus
Measure the vertical diameter，transverse diameter and anteroposterior diameter of uterus in millimeters
Time frame: 1/4/2018-24/12/2020
Antral follicle count
Measure the basic antral follicle count before controlled ovarian hyperstimulation.
Time frame: 1/4/2018-24/12/2020
Endometrial thickness
Measure endometrial thickness of subjects in millimeters.
Time frame: 1/4/2018-24/12/2020
Live birth rate
Record the live birth rate of offspring in in both groups.
Time frame: 1/4/2018-24/12/2020
Neonatal weight
Record the neonatal weight(in kilogram) of offspring in two groups.
Time frame: 1/4/2018-24/12/2020
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