Brentuximab Vedotin as Alternative to the Autologous Stem Cell Transplantation in Relapsed and Refractory Classical Hodgkin's Lymphoma (BASALT)

Inclusion Criteria: 1. Male or female patients 18 years or older 2. Voluntary written informed consent must be given before performance of any study-related procedure not part of standard medical care, with the understanding that consent may be withdrawn by the patient at any time without prejudice to future medical care. 3. Female patient is either post-menopausal for at least 1 year before the screening visit or surgically sterile or if of childbearing potential, agree to practice 2 effective methods of contraception, at the same time, from the time of signing the informed consent through 6 months after the last dose of study drug, or agrees to completely abstain from heterosexual intercourse. 4. Male patients, even if surgically sterilized, (i.e., status post vasectomy) agree to practice effective barrier contraception during the entire study period and through 6 months after the last dose of study drug, or agrees to completely abstain from heterosexual intercourse. 5. Patients must have a diagnosis of a morphologically confirmed cluster of differentiation antigen 30 {CD30)-positive classical Hodgkin's lymphoma with primary refractory course or relapse after adequate first-line chemotherapy (with morphologically confirmation of vital tumor) 6. PET-positive measurable disease (at least one lesion with Deauville score of \>3 and at \>1.5 cm on CT scan) 7. Performance status Eastern Cooperative Oncology Group (ECOG) \<3 8. Patients potentially eligible for subsequent ASCT according treating physician decision 9. Clinical laboratory values as specified below within 7 days before the first dose of study drug: * Absolute neutrophil count ≥ 1,500/µL unless there is known hematologic/solid tumor marrow involvement * Platelet count ≥ 75,000/ µL unless there is known marrow involvement of the disease * Total bilirubin must be \< 1.5 x the upper limit of the normal (ULN) unless the elevation is known to be due to Gilbert syndrome. * ALT or aspartate aminotransferase (AST) must be \< 3 x the upper limit of the normal range. AST and ALT may be elevated up to 5 times the ULN if their elevation can be reasonably ascribed to the presence of HL tumor in liver. * Serum creatinine must be \< 2.0 mg/dL and/or creatinine clearance or calculated creatinine clearance \> 40 mL/minute. * Hemoglobin must be ≥ 8g/dL. Exclusion Criteria: 1. More than one line of chemotherapy due to Classical Hodgkin's lymphoma (any salvage treatment) 2. Previous treatment with brentuximab vedotin 3. Female patient who are both lactating and breast-feeding or have a positive serum pregnancy test during the screening period 4. Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to the protocol. 5. Known cerebral or meningeal disease (HL or any other etiology), including signs or symptoms of progressive multifocal leukoencephalopathy (PML) 6. Symptomatic neurologic disease compromising normal activities of daily living or requiring medications 7. Any sensory or motor peripheral neuropathy greater than or equal to Grade 2 8. Known history of any of the following cardiovascular conditions * Myocardial infarction within 2 years of enrollment * New York Heart Association (NYHA) Class III or IV heart failure (see appendix #1) * Evidence of current uncontrolled cardiovascular conditions, including cardiac arrhythmias, congestive heart failure (CHF), angina, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities * Recent evidence (within 6 months before first dose of study drug) of a left-ventricular ejection fraction \<50% 9. Any active systemic viral, bacterial, or fungal infection requiring systemic antibiotics within 2 weeks prior to first study drug dose 10. Patients that have received other investigational agents within at least 5 half-lives of last dose of that prior treatment 11. Known hypersensitivity to recombinant proteins, murine proteins, or to any excipient contained in the drug formulation of brentuximab vedotin. 12. Known human immunodeficiency virus (HIV) positive 13. Known hepatitis B surface antigen-positive, or known or suspected active hepatitis C infection 14. Diagnosed or treated for another malignancy. Patients with nonmelanoma skin cancer or carcinoma in situ of any type are not excluded if they have undergone complete resection.