A Prospective Cohort Study for Patients With Adrenal Diseases

N/AEnrolling By InvitationNCT03474237

Seoul National University Hospital1,500 enrolled

Overview

The purpose of this study is to investigate the pathologic features, complications, and prognostic factors of functioning adrenal adenoma and suggest follow-up algorithms for adrenal incidentaloma.

The investigators will recruit 150 patients annually for 10 years (adrenal incidentaloma 100 patients, pheochromocytoma 15 patients, primary aldosteronism 25 patients, adrenal cushing syndrome 10 patients, adrenocortical carcinoma 2 patients) and perform hormonal, biochemical, imaging exam according to each disease's clinical guidelines. Based on this, the investigators will identify pathologic features, complications, and prognostic factors of each disease.

Study Type

OBSERVATIONAL

Enrollment

1,500

Conditions

Adrenal Adenoma Cushing Syndrome Pheochromocytoma Adrenal Incidentaloma Adrenocortical Carcinoma Primary Hyperaldosteronism

Interventions

Hormone study and Imaging studyOTHER

1. Blood (basal hormone and follow up hormone study) 2. Imaging examination including computed tomography scan or magnetic resonance imaging

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults, male or female aged 19 years or older * newly diagnosed with adrenal disease such as adrenal incidentaloma, pheochromocytoma, primary aldosteronism, adrenal cushing syndrome, adrenocortical carcinoma Exclusion Criteria: * previous or current history of adrenal diseases * using oral or intravenous steroids * history of major depressive disorder * history of chronic alcoholics * history of any cancer with suspicious adrenal metastasis * those with acute illness (ex- patients with acute coronary syndrome within 4 weeks, acute febrile disease)

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Number of participants in remission

Remission rate

Time frame: Up to 10 years

Secondary Outcomes

Complication of adrenal disease

all complications including deaths

Time frame: Up to 10 years

Data from ClinicalTrials.gov

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