FabLife is an interventional, prospective, multicentre, controlled study undertaken in metropolitan France. The main objective is to evaluate the effect of FabLife personalised program over a period of 15 weeks on the improvement of spermatic DNA fragmentation in subfertile men compared to general dietary recommendations.
More than 15 % of couples couldn't get pregnant after at least a year of unprotected intercourse. The FabLife personalised program aims to improve sperm quality including sperm DNA fragmentation in subfertile men through: * A personalized dietary program based on patient's phenotype and genotype * A daily dietary supplement, developed in the context of male infertility A total of 75 patients will be recruited: * 46 patients will benefit from the program, * 23 patients will form the control group. * 6 patients will not answer to all the criteria.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
75
* A personnalized dietary program depending on the patient's phenotype and genotype * The daily intake of a dietary supplement, developped in the context of male infertility.
Drouot Laboratory
Paris, France
RECRUITINGTenon Hospital (AP-HP)
Paris, France
NOT_YET_RECRUITINGSperm DNA fragmentation
Difference in sperm DNA fragmentation from baseline to post-treatment
Time frame: 15 weeks
Semen quality
Difference in semen quality (semen variables including total sperm count, sperm concentration, sperm motility, sperm morphology and semen volume) from baseline to post-treatment.
Time frame: 15 weeks
Sperm motility
Difference in sperm motility from baseline to post-treatment.
Time frame: 15 weeks
Sperm morphology
Difference in sperm morphology from baseline to post-treatment.
Time frame: 15 weeks
Sperm concentration
Difference in sperm concentration from baseline to post-treatment.
Time frame: 15 weeks
Semen volume
Difference in semen volume from baseline to post-treatment.
Time frame: 15 weeks
Total sperm count
Difference in total sperm count from baseline to post-treatment.
Time frame: 15 weeks
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