Combined analysis of functional and structural language network changes may be a good model for predicting language outcome.
Background \& objectives: Language impairment after aphasic stroke is both common and debilitating. However the mechanisms of language recovery after aphasic stroke is not fully understood. Investigators plan to detect the changes of functional and structural language networks after aphasic stroke by high-resolution MRI.Then Combined analyse functional and structural language network changes, establishing a prediction model for language outcome. Methods: The proposed study is a observational trial that will include 50 patients diagnosed with post stroke aphasia from the neurology clinics at The First Affiliated Hospital, Zhejiang University. Aphasia battery of Chinese(ABC) and functional magnetic resonance imaging (MRI) will be performed at acute(\~2weeks),subacute(3 months) and chronic phase(6months). Only routine drug therapy will be used. Relevance: Currently there is little known about the recovery mechanisms of post-stroke aphasia.The proposed study intends to analyse functional and structural language network changes by high resolution MRI, which may reveal the potential recovery mechanism underlying post stroke aphasia..
Study Type
OBSERVATIONAL
Enrollment
50
The First Affiliated Hospital, Zhejiang University
Hangzhou, Zhejiang, China
Resting state functional connectivity changes
The study uses resting state functional MRI(rs-fMRI) to measure changes of functional connectivity across regions after a spontaneous recovery.
Time frame: 3 months
Aphasia Battery of Chinese, ABC
ABC, the Chinese standardized adaptation of the Western Aphasia Battery, indicates the patient's ability of spontaneous speech, auditory comprehension, repetition, naming, reading, writing.
Time frame: 3 months
White matter Integrity
The study uses Diffusion tensor imaging and tracking (DTI) to measure changes of the Integrity of white matter after a spontaneous recovery.
Time frame: 3 months
Brain response change
The study uses task functional MRI (fMRI) to measure the brain response changes during the task after a spontaneous recovery.
Time frame: 3 months
Resting state functional connectivity changes
The study uses resting state functional MRI(rs-fMRI) to measure changes of functional connectivity across regions after a spontaneous recovery.
Time frame: 6 months
Aphasia Battery of Chinese, ABC
ABC, the Chinese standardized adaptation of the Western Aphasia Battery, indicates the patient's ability of spontaneous speech, auditory comprehension, repetition, naming, reading,
Time frame: 6 months
White matter Integrity
The study uses Diffusion tensor imaging and tracking (DTI) to measure changes of the Integrity of white matter after a spontaneous recovery.
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Time frame: 6 months
Brain response change
The study uses task functional MRI (fMRI) to measure the brain response changes during the task after a spontaneous recovery.
Time frame: 6 months