Effects of Gastric Bypass Surgery on Bile Acid Homeostasis

Hvidovre University Hospital40 enrolled

Overview

The purpose of this study is to determine whether the bile acid circulation is changed after gastric bypass surgery. Further, to account for how the changed anatomy of the gut influences how the bile acid and food is mixed in the gut and how this is associated with the changes in gut hormone release after the surgery. Our hypothesis is that bile acid reabsorption from the gut is increased as animal models suggest so and bile acid blood concentration increases after surgery.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity

Eligibility

Sex: ALLMin age: 25 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 25 and 65 years * For patients: uncomplicated Roux-en-Y Gastric Bypass surgery more than 12 months before study initiation * For controls: Age, BMI and gender matched with patient group Exclusion Criteria: * Previous removal of gall bladder or other abdominal surgeries except appendectomy (and gastric bypass surgery for patient group) * Known liver disease or thyroid disease requiring antithyroid medication * Chronic gastrointestinal symptoms * Any chronic disease interfering with, or susceptive of interfering with appetite or gastrointestinal function * Any medication interfering with, or susceptive of interfering with appetite or gastrointestinal function * Smoking within the last month * Alcohol consumption above 168 grams per week * Currently pregnant or breast-feeding * Anaemia with haemoglobin \<6,5 mmol/L (\<117 mg/dl) * Loss or gain of more than 3 kg within the last 3 months

Locations (1)

Department of Endocrinology at Hvidovre University Hospital

Hvidovre, Copenhagen, Denmark

Outcomes

Primary Outcomes

Differences in time from food intake to mix of food in the gut with bile acid between patients and controls

Time frame: Patients: >12 months after Gastric Bypass Surgery

Percentage of orally ingested exogenic bile acid that is retained in the body after 7 days

Time frame: Patients: >12 months after Gastric Bypass Surgery

Data from ClinicalTrials.gov

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