The primary objectives of this study are to define the extent of dermatomal anesthesia and anatomical spread of injectate (as defined by MRI imaging) that is provided by an ESP block at the T5 level, using twenty milliliters of 0.5% ropivacaine. The secondary objectives include: 1) the measurement of changes in hemodynamic parameters associated with the ESP block, 2) the duration of sensory effects provided by ropivacaine with or without epinephrine, 3) the venous plasma concentration of ropivacaine associated at various time intervals after completion of the ESP block.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
12
injection of 20mL of 0.5% Ropivacaine at the left or right T5 transverse process
injection of 20mL epinephrine in combination with ropivacaine at the left or right T5 transverse process
Milton S.Hershey Medical center
Hershey, Pennsylvania, United States
Area of Dermatomal Sensory Loss at 20 Min
A consultant anesthesiologist blinded to the randomization allocation will perform a sensory assessment for loss of sensation to cold using ethanol on the skin
Time frame: 20 minutes from the time of the ESP block
Area of Dermatomal Sensory Loss 60 Min
A consultant anesthesiologist blinded to the randomization allocation will perform a sensory assessment for loss of sensation to cold using ethanol on the skin
Time frame: 60 minutes from the time of the ESP block
Area of Dermatomal Sensory Loss 120 Min
A consultant anesthesiologist blinded to the randomization allocation will perform a sensory assessment for loss of sensation to cold using ethanol on the skin
Time frame: 120 minutes from the time of the ESP block
Area of Dermatomal Sensory Loss at 240 Min
A consultant anesthesiologist blinded to the randomization allocation will perform a sensory assessment for loss of sensation to cold using ethanol on the skin
Time frame: 240 minutes from the time of the ESP block
Area of Dermatomal Sensory Loss 360 Min
A consultant anesthesiologist blinded to the randomization allocation will perform a sensory assessment for loss of sensation to cold using ethanol on the skin
Time frame: 360 minutes from the time of the ESP block
Venous Plasma Concentration of Ropivacaine at 20 Min
3 ml of blood will be obtained from the Intravenous line already placed in the subject prior to performing the block.
Time frame: These samples will be repeated at 20 minutes after completion of the injection of active drug.
Venous Plasma Concentration of Ropivacaine at 60 Min
3 ml of blood will be obtained from the Intravenous line already placed in the subject prior to performing the block.
Time frame: These samples will be repeated at 60 minutes after completion of the injection of active drug.
Venous Plasma Concentration of Ropivacaine at 90 Min
3 ml of blood will be obtained from the Intravenous line already placed in the subject prior to performing the block.
Time frame: These samples will be repeated at 90 minutes after completion of the injection of active drug.
Venous Plasma Concentration of Ropivacaine at 120 Min
3 ml of blood will be obtained from the Intravenous line already placed in the subject prior to performing the block.
Time frame: These samples will be repeated at 120 after completion of the injection of active drug.
Venous Plasma Concentration of Ropivacaine at 240 Min
3 ml of blood will be obtained from the Intravenous line already placed in the subject prior to performing the block.
Time frame: These samples will be repeated at 240 minutes after completion of the injection of active drug.
Volume of Injectate Spread Measured Using MRI at 30 Min
The subject will undergo two MRIs to determine the spread of the anesthetic.
Time frame: 30 minutes from the time of the ESP block
Volume of Injectate Spread Measured Using MRI at 90 Min
The subject will undergo two MRIs to determine the spread of the anesthetic.
Time frame: 90 minutes from the time of the ESP block
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