Full ambulatory polysomnography at home performed two nights in 30 healthy children and one night in 30 children with mono-symptomatic nocturnal enuresis (15 with polyuria and 15 without polyuria). The children will be aged 7-14 years of age. The sleep will be evaluated on sleep quality, number of periodic limb movements per hour, blood pressure and pulse, beat to beat variation by electrocardiography during sleep, respiration during sleep, nocturnal urine production, and enuresis episodes.
Purpose and perspectives: The purpose of the study is to investigate the quality of sleep, the sleep architecture and the intra-individual variation from night to night in healthy children and children with mono-symptomatic nocturnal enuresis (MNE) using full polysomnography at home. Hypotheses: * There is large intra-individual night to night variation in sleep quality and architecture. * Children with MNE have different sleep architecture than healthy children when looking at sleep quality and arousals. * Periodic limp movements at sleep is more frequent in children with MNE than in healthy children. Design: The study is a case-control study. Materials and methods: The study will recruit 30 healthy children and 30 children with MNE (15 with polyuria and 15 without polyuria) recruited from the Childrens Incontinence Center at the Department of Pediatrics and Adolescent Medicine at Aarhus University Hospital. Children of both sexes aged between 7 and 14 years of age will be enrolled. Children and their parents will be informed about the study both verbally and in written. Written informed consent from both parents must be obtained before the children can be enrolled in the study. The healthy children will go through two nights of full polysomnography to be able to view intra-individual changes. The children with MNE will only have to do one night of polysomnography. Primary parameters: * Sleep quality * Number of periodic limb movements per hour * Blood pressure and pulse * Beat to beat variation by electrocardiography during sleep * Respiration during sleep * Nocturnal urine production * Enuresis episodes
Study Type
OBSERVATIONAL
Enrollment
60
For the healthy children two nights of polysomnography. For the children with nocturnal enuresis one night of polysomnography.
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital
Aarhus, Aarhus N, Denmark
RECRUITINGSleep efficiency
Sleep efficiency will be calculated as the ratio of the total time spent asleep to the total time spent in bed
Time frame: One night of polysomnography.
Periodic limb movements during sleep
Number of periodic limb movements per hour at sleep compared between the three groups.
Time frame: One night of polysomnography.
Nocturnal urine production
We will compare the nocturnal urine production in millilitres in the three groups.
Time frame: One night of polysomnography.
Enuresis episodes
We are going to look at the time of the enuresis episode and compare it to the polysomnographic findings at that time.
Time frame: One night of polysomnography
Respiratory events during sleep
Respiration during sleep comparison between the three groups. This includes saturation, nasal air flow and movement of the stomach and chest. Together showing the number of respiratory events (apneas/hour).
Time frame: One night of polysomnography
Incidence of sleep disturbances
Percentage of children with clinical sleep disturbances between patients and controls
Time frame: One night of polysomnography
Intra-individual differences in sleep efficiency from night to night in healthy controls.
Sleep efficiency (in percent) will be compared between the two nights of polysomnography in the healthy controls.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: Two nights of polysomnography. Each evaluated after completing the two nights.
Intra-individual differences in periodic limb movements during sleep from night to night in healthy controls.
Periodic limb movements during sleep will be compared between the two nights of polysomnography in the healthy controls.
Time frame: Two nights of polysomnography. Each evaluated after completing the two nights.
Intra-individual differences in nocturnal urine production from night to night in healthy controls.
Nocturnal urine production will be compared between the two study nights in the healthy controls.
Time frame: Two nights of polysomnography. Each evaluated after completing the two nights.
Intra-individual differences in respiratory events from night to night in healthy controls.
The number and kinds of respiratory events will be compared between the two study nights in the healthy controls.
Time frame: Two nights of polysomnography. Each evaluated after completing the two nights.