Comparison of Different Protocols of Fluid Therapy in Severe Preeclamptic Patients Under Spinal Anesthesia

Early Phase 1UnknownNCT03478618

Assiut University60 enrolled

Overview

To compare the effect of two different protocol of fluid therapy in sever preeclamptic patients under spinal anesthesia : Hemodynamic and kidney function .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Hypotension Drug-Induced

Interventions

Lactated RingerDRUG

Patients will be divided into 2 groups according to the amount of fluids received during caesarian section under spinal anesthesia. Group (R) 30 patients will receive 15ml/kg/h lactated Ringer (LR) intraoperative. Group (L) 30 patients will receive 30ml/kg/h lactated Ringer (LR) intraoperative. blood loss will be replaced if more than 500 ml in ratio 3 ml crystalloid : 1ml blood in both groups

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * more than 36 weeks gestation * singleton pregnant women planned for elective caesarian section Exclusion Criteria: * patient refusal. * psychiatric disorders. * parturient \<36 weeks gestation, twins, abnormal cardiotocography (CTG) tracing. * absolute contraindications for spinal anesthesia (patients refusal, raised intracranial pressure, hypovolemic states, abnormal coagulopathy).

Outcomes

Primary Outcomes

incidence of hypotension

decrease in systolic blood pressure more than 20% of base line

Time frame: 1 hour

Central Contacts

Zein El Abadin Zarae Hassan, PhD

CONTACT

01005187371 zein20002002@yahoo.com

Data from ClinicalTrials.gov

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