Usefulness of Lidocaine in Oral and Maxillofacial Surgeries Under General Anesthesia for Pain Control After Operation

B.P. Koirala Institute of Health Sciences40 enrolled

Overview

This will be a randomized double blinded clinical study conducted in patients undergoing oral and maxillofacial surgery under general anesthesia. Lidocaine group will receive intravenous bolus 1.5 mg/kg at induction followed by continuous infusion of 2 mg/kg/hr until the completion of surgery.Normal saline group will receive same amount of intravenous normal saline .The primary outcome will be postoperative pain using the NRS scale during first 24 hours and time to first analgesic request

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Pain, Postoperative

Interventions

Lidocaine

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients 18-60 years of age * Patients of ASA (American Society of Anesthesiologists) Class I or Class II (I- healthy with no systemic disease, II- mild systemic disease with no functional limitation) who require oral and maxillofacial surgeries under general anesthesia Exclusion Criteria: * Refusal to give consent. * Hypersensitivity or allergy to the study medication. * ASA physical status III or more. * Subjects with known severe hepatic or renal dysfunction or cardiac dysrhythmia or atrioventricular block. * History of taking opioids or antiarrhythmic drugs within 1 week of surgery. * History of drug or alcohol abuse * History of psychiatric disorders. * Patients requiring emergency surgery. * Patients unable to comprehend pain assessment

Outcomes

Primary Outcomes

Postoperative Numeric Rating Scale(NRS)

Pain at rest and with cough or movement using the NRS scale, which ranges from 0 to 10; where 0 refers to no pain and 10 refers to most severe pain

Time frame: 24 hours

Secondary Outcomes

Total opioid consumption

Total morphine or morphine equivalent in milligram

Time frame: 24 hours

Time to first analgesic request

Time to first analgesic (ketorolac) request (time counted after skin closure)

Time frame: 24 hours

Side effects

Number of patients with light headedness, sedation, nausea, vomiting will be documented

Time frame: 24 hours

Usefulness of Lidocaine in Oral and Maxillofacial Surgeries Under General Anesthesia for Pain Control After Operation

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes