Clinical, Meibographic and Interferometric Evaluation of Phlyctenular Keratitis in Children - MEIBO-ROSACEE

Fondation Ophtalmologique Adolphe de Rothschild102 enrolled

Overview

The aim of this study is to describe the clinical, meibographic and interferometric manifestations of phlyctenular keratitis in children.

The investigators are conducting a monocentric, transversal, epidemiologic study. 100 patients should be included: 50 children suffering from ocular rosacea, and 50 children with no palpebral or Meibomian disease. Witnesses will be matched on the age of the cases. Patient and controls will undergo a classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, the child will go through a meibographic and interferometric evaluation of his two inferior eyelids. This evaluation is made by an optometrist with the Lipiview device, and lasts a few minutes.

Study Type

OBSERVATIONAL

Enrollment

102

Conditions

Ocular Rosacea Keratoconjunctivitis Meibomian Gland Dysfunction

Interventions

Ophthalmologic examination and meibographic and interferometric evaluation (Lipiview device)PROCEDURE

Classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, meibographic and interferometric evaluation of his two inferior eyelids with the Lipiview device.

Eligibility

Sex: ALLMin age: 2 YearsMax age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Recruited from a specialized ophthalmologic consultation Rothschild Ophthalmologic Foundation, Paris, France. * Cases : suffering from ocular or oculo-cutaneous rosacea * Witnesses : without any present or past palpebral or meibomian disease Exclusion Criteria: * Unable to achieve the meibographic and interferometric examination (Lipiview)

Locations (1)

Fondation Ophtalmologique A. de Rothschild

Paris, France

Outcomes

Primary Outcomes

Clinical severity

Clinical severity is determined with a composite score, by the presence of chalazia, corneal lesions, neovascularization, phlyctena, loss of vision, superficial keratitis, anterior and posterior keratitis, meibomitis, palpebral margin keratinization, lagophthalmos, long term use of azithromycin treatment, treatment by ciclosporin eyedrops, intense cutaneous or ocular symptoms, long time evolution of the disease.

Time frame: Day of inclusion

Meibographic severity

The meibographic severity is determined by the level of Meibomian gland atrophy, data obtained with the Lipiview

Time frame: Day of inclusion

Interferometric severity

The interferometric severity is evaluated by the thickness of the lipid layer tear film, data obtained with the Lipiview

Time frame: Day of inclusion

Number of abortive blinks

Number of abortive blinks during the Lipiview exam

Time frame: Day of inclusion

Data from ClinicalTrials.gov

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