Response evaluation with FDG-PET and free circulating DNA in patients with inoperable lung cancer of non small cell type during first treatment with chemotherapy or immunotherapy.
Interventional study of patients with inoperable lung cancer of non small cell type undergoing 1st treatment of either chemotherapy or immunotherapy. Patients are evaluated with FDG-PET/ct and blood analyses og circulating tumor DNA and cancer markers to determine early response. PET-CT are preceded before and after treatment is given; * day 0 before treatment, * day 2 after treatment and * day 21 just before second treatment. At every FDG-PET/ct scan blood are examined for circulating tumor DNA (ctDNA) and potentially cancer markers by White genome sequencing. In total 3 PET-CT scans and 4 blood samples are performed. The result are compared with the standard CT scan after 2-3 cycles of treatment. Blood analyses are repeated after 2-3 cycles to observe any changes.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
60
3 extra scans with FDG-PET/CT and 4 blood samples
University Copenhagen
Copenhagen, Denmark
NOT_YET_RECRUITINGUniversity of Copenhagen
Copenhagen, Denmark
RECRUITINGObservation of changes in metabolism in cancer cells during first treatment with chemotherapy or immunotherapy.
Measure changes in standardized uptake value (SUV) in tumorcells by FDG-PET.
Time frame: 3 months
Observation of changes in circulating tumor DNA during first treatment.
Measure changes in the amount of free circulating DNA
Time frame: 3 months
Observation of changes in circulating tumor DNA during first treatment.
Measure changes in cancer DNA by whole genome sequencing on free circulating DNA.
Time frame: 3 months
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