This is a prospective study of children \<21 years of age with the goal of characterizing the PK of drugs administered per standard of care as prescribed by the treating caregiver.
Study Type
OBSERVATIONAL
Enrollment
200
This study is collecting PK data on children prescribed the following drugs of interest per standard of care: dexmedetomidine, bosentan, furosemide, chlorothiazide, ethacrynic acid, bumetanide, hydromorphone, tacrolimus, ampicillin, gentamicin, caffeine, fentanyl, midazolam, foscarnet, hydroxychloroquine, and moxifloxacin.
Duke University
Durham, North Carolina, United States
RECRUITINGArea under the curve (AUC)
Time frame: Data will be collected throughout the hospital or outpatient stay up to 90 days
Maximum concentration (Cmax)
Time frame: Data will be collected throughout the hospital or outpatient stay up to 90 days
Time to achieve maximum concentration (Tmax)
Time frame: Data will be collected throughout the hospital or outpatient stay up to 90 days
Absorption rate constant (ka)
Time frame: Data will be collected throughout the hospital or outpatient stay up to 90 days
Elimination rate constant (kel)
Time frame: Data will be collected throughout the hospital or outpatient stay up to 90 days
Half-life (t1/2)
Time frame: Data will be collected throughout the hospital or outpatient stay up to 90 days
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