Effect of Monosaccharides on Intestinal Barrier Function

Prof. Dr. Ina Bergheim12 enrolled

Overview

The aim of the present study is to determine the effect of monosaccharides on intestinal barrier function in healthy subjects.

In the intervention study normal weight participants will receive defined amounts of monosaccharides for several days. Before and after intervention parameters of intestinal barrier function will be assessed.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Dietary Habits Endotoxemia

Interventions

Dietary InterventionOTHER

Participants receive different monosaccharides for a defined number of days.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI \<25 kg/m2 * no kown history of metabolic disorders or fatty liver Exclusion Criteria: * food allergies or intolerances (esp. fructose intolerance and malabsorption) * renal insufficiency * chronic disease of the gastrointestinal tract * taking drugs affecting lipid or glucose metabolism

Outcomes

Primary Outcomes

Changes in parameters of intestinal barrier function

Changes in endotoxin plasma levels

Time frame: 1 week

Secondary Outcomes

Changes in blood pressure

Changes in systolic and diastolic blood pressure

Time frame: 1 week

Changes in markers for glucose metabolism

Changes in fasting glucose and fasting insulin levels

Time frame: 1 week

Changes in blood lipid levels

Changes in triglyceride levels

Time frame: 1 week

Changes in Uric Acid levels

Changes in Uric Acid blood levels

Time frame: 1 week

Data from ClinicalTrials.gov

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