Alcohol and Immune Response

Brown University76 enrolled

Overview

This study investigates how alcohol affects the immune system and behavior in healthy adults. The study also will examine how an individual's typical drinking habits may affect the immune system's response to alcohol.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Alcohol Drinking Alcohol; Harmful Use

Interventions

Alcohol, EthylDRUG

Randomized within-subjects design

Alcohol, Ethyl - placeboOTHER

Randomized within-subjects design

Eligibility

Sex: ALLMin age: 21 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Ages 21-55 years * Able to speak and read English * Regular use of alcohol * Weight \> or = to 110 lbs and body mass index (BMI) in the 18.5-30 kg/m2 range * No self-reported use of drugs Exclusion Criteria: * Currently seeking treatment for alcohol or drug use * Chronic disease * Use of certain medications * GI disorders * Daily/near-daily use of NSAIDs * Positive urine test for certain drugs * History of withdrawal symptoms precipitated by alcohol abstinence * Clinical Institute Withdrawal Assessment for Alcohol score greater than or equal to 10 * History of seizures * Current major psychiatric disorder * History of adverse reaction to standard blood draw * Inability to abstain from tobacco for 8 hours * Inability to abstain from cannabis for 48 hours * Pregnant, breastfeeding, or may become pregnant

Locations (1)

Brown University

Providence, Rhode Island, United States

Outcomes

Primary Outcomes

Plasma lipopolysaccharide (pg/ml)

Plasma concentration of lipopolysaccharide, measured in picograms/ml

Time frame: 0-4 hours

Plasma lipopolysaccharide binding protein (ng/ml)

Plasma concentration of lipopolysaccharide binding protein, measured in nanograms/ml

Time frame: 0-4 hours

Soluble cluster of differentiation 14 (ng/ml)

Plasma concentration of soluble cluster of differentiation 14, measured in nanograms/ml

Time frame: 0-4 hours

Soluble cluster of differentiation 163 (ng/ml)

Plasma concentration of soluble cluster of differentiation 163, measured in nanograms/ml

Time frame: 0-4 hours

Secondary Outcomes

Response time in ms

Response time in milliseconds, as measured by the NIH Toolbox and Cued Go/No-Go test

Time frame: 0-4 hours

Data from ClinicalTrials.gov

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