Infiltrations of OnaBotulinum Toxin A in Resistant Depression: Comparison of Two Facial Injection Sites.

Inclusion Criteria: * Male or female from 18 to 80 years old included * Inpatient or ambulatory patients treated for resistant depressive episode, that is to say by an absence of symptomatic remission (nonresponse or partial response) after the use of two successive trials of antidepressants of different pharmacological class, well conducted in terms of dosage and duration, while ensuring quality adherence (at least 80% of the treatment taken during the period considered) * Diagnosis according to DSM-5 depressive episode characterized with MADRS score\> 20 * Women of childbearing potential must have an effective method of contraception (failure rate \<1% per year with correct use): IUD, pill, ... (participant statement) * Patient able to adhere to the restrictions and prohibitions of the protocol * Patient agreeing to sign an informed consent Exclusion Criteria: * Current psychiatric comorbidity * Severe intellectual disability * Known hypersensitivity to botulinum toxin type A or any of the excipients * Myasthenia gravis * Presence of infection at the injection site (s) * Participation in an interventional clinical study. * Pregnant woman, breastfeeding, or who plans to be pregnant during the study or within 6 weeks after the last administration of the treatment. * Any patient already receiving aesthetic treatment