Open clinical study to evaluate the soothing activity of a body cream to be applied once a day, mono-laterally at level of the antecubital fold and forearm, for an uninterrupted period of 1 month, by 22 adult volunteers, with positive anamnesis for atopy and habitual itching.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
22
The study cream was applied once a day (at the morning or at the evening), preferentially always at the same hour, with a mild massage, for an uninterrupted period of 1 month
DERMING
Milan, MI, Italy
Change from baseline of Transepidermal water loss (TEWL)
The measurement of TEWL, performed by the use of Tewameter® TM300, allows to objectively monitor skin responses to cosmetic treatments. A shift from low-normal rates of TEWL to high levels is due to barrier disruption.
Time frame: Baseline (T0), 1 month (T1), 2 months (T2)
Change from baseline of Superficial skin hydration
Skin electrical capacitance value is measured with Corneometer CM825
Time frame: Baseline (T0), 1 month (T1), 2 months (T2)
Change from baseline of Deep skin hydration
Tissue dielectric constant of deep skin layers is measured with MoistureMeterD
Time frame: Baseline (T0), 1 month (T1), 2 months (T2)
Change from baseline of Epicutaneous pH
Surface cutaneous pH is measured with pH meter HI5221
Time frame: Baseline (T0), 1 month (T1), 2 months (T2)
Change from baseline of Surface microrelief's regularity
Surface microrelief's regularity is performed on skin replicas images acquired by Primos
Time frame: Baseline (T0), 1 month (T1), 2 months (T2)
Change from baseline of itching sensation
Each volunteers scored its own itching sensation thanks to a visual analogic scale (VAS from 0 = no itching to 10= strong itching).
Time frame: Baseline (T0), 1 month (T1), 2 months (T2)
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