A Clinical Study to Evaluate TV003 in Healthy Adults in Taiwan

Inclusion Criteria: * Adult male or female between 20 and 70 years of age * Good general health as determined by physical examination, laboratory screening, and review of medical history * Available for the duration of the study * Willingness to sign the informed consent document * Female of childbearing potential willing to use effective contraception for the duration of the trial Exclusion Criteria: * Females currently pregnant, as determined by positive β- human choriogonadotropin (HCG) test, and/or breast-feeding. * Evidence of clinically significant neurologic, cardiac, pulmonary, hepatic, rheumatologic, autoimmune, or renal disease by history, physical examination, and/or laboratory studies * Behavioral, cognitive, or psychiatric disease * Below lower limit of normal for absolute neutrophil count * Any significant alcohol or drug abuse in the past 12 months * History of a severe allergic reaction or anaphylaxis * Self-reported systemic hypersensitivity to any of the vaccine components * Severe asthma * Known HIV, Hepatitis B or hepatitis C * Any known immunodeficiency syndrome * Use of anticoagulant medications * Receive chronic administration of immunosuppressant drugs within 6 months prior to the administration of the study vaccine * Use of any investigational product within 30 days before study vaccination or at any time during the study * Asplenia * Receive administration of immunoglobulins and/or any blood products within 12 months preceding the administration of the study vaccine or at any time during the study * Fever or suspected fever within 72 hours prior to vaccination or tympanic temperature greater than 38°C on the day of vaccination * Receive administration of any licensed live attenuated vaccines within 30 days preceding the administration of the study vaccine and ending 30 days after * Receive administration of any licensed inactivated vaccines within 14 days preceding the administration of the study vaccine and ending 14 days after * Any other condition that in the opinion of the investigator would jeopardize the safety or rights of a subject participating in the trial or would render the subject unable to comply with the protocol