Administration of antiretroviral therapy has brought benefits for infective human immunodeficiency virus-1 (HIV-1)-patients, reducing the number of AIDS-related morbidity and mortality. However, it is responsible for intensifying complications triggered by the chronic inflammatory state associated with virus infection, such as cardiovascular diseases. The current study evaluated effects of single dose (140mL) of Beetroot Juice (BJ) on macro and microvascular endothelial function in HIV-1-patients undergoing antiretroviral terapy, once BJ was shown to be effective in improving these physiological parameters in uninfected individuals.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
12
140ml of Beetroot Juice containing on avarege 9 mmol of nitrate
140ml of Beetroot Juice (nitrate free)
DST / AIDS and Viral Hepatitis Program of Macaé
Macaé, Rio de Janeiro, Brazil
Skeletal Muscle Oxygenation
Changes in skeletal muscle oxygenation in response to exercise will be evaluated by using a near-infrared spectroscopy device.
Time frame: Baseline and approximately after 150 minutes of beetroot juice consumption
Brachial artery flow-mediated dilatation
The brachial artery flow-mediated dilation will be evaluated by using an ultrasound device.
Time frame: Baseline and approximately after 150 minutes of beetroot juice consumption
Urinary nitrate concentrations
Analysis of nitrate in urine will be performed by using high-performance liquid chromatography system.
Time frame: Baseline and approximately 30, 90, and 150 minutes after beetroot juice consumption
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.