Metabolic Dynamics During Physical Activity

Charite University, Berlin, Germany34 enrolled

Overview

The aim of this study is to systematically Analyse the metabolome in capillary blood of healthy men and women at rest and during defined standardized physical activity under normobaric normoxia or hypoxia with a specific focus on metabolites and metabolic pattern related to energy metabolism. The metabolome analyses in capillary blood could give us also or more detailed insight into erythrocyte metabolic physiology because it is known for a longer time that the primary metabolism of the erythrocyte reflects its Oxygen Saturation via the glycolytic metabolites / intermediates pattern.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Healthy Men and Women

Interventions

running on a treadmill under normoxia or hypoxiaOTHER

* 30 min running (60% VO2max) on a treadmill under hypoxia (O2: 14%) * 30 min running (60% VO2max) on a treadmill under normoxia (O2: 20%)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy volunteers * written informed consent Exclusion Criteria: * known cardio-vascular, lung, metabolic, endocrine, hematologic, kidney or neurologic diseases * pregnancy, lactating period * unability to understand study content and aims and to give written informed consent

Locations (1)

Charite University Medicine, ECRC

Berlin, Germany

Outcomes

Primary Outcomes

Change in capillary lactate/pyruvate Ratio (dimension-free)

marker for the ratio between anaerobic / aerobic glycolysis

Time frame: t = 0 min (before exercise); t = 10, 20 and 30 min during exercise; t = 50 and 60 min during recovery

Data from ClinicalTrials.gov

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