Retrospective inclusion of lung cancers developed in a context of idiopathic pulmonary fibrosis, diagnosed and / or treated in participating centers. The cases are recovered retrospectively from the records of the pulmonology and pathology departments of our various partners.
Primary objective: Characterize altered molecular pathways in lung cancer in patients with IPF versus lung cancer in non-IPF patients. Secondary objectives: Identify specific therapeutic targets Describe a cohort of lung cancers on IPF (clinical / radiological and pathological data) To study the relationship between neoplastic / preneoplastic lesions and pulmonary parenchyma reshaped by fibrosis.
Study Type
OBSERVATIONAL
Enrollment
100
Hopital BICHAT-CLAUDE BERNARD
Paris, France
Molecular profile of IPF-associated lung carcinomas
Next generation sequencing of carcinomas with Ion S5 XL sequencer and Oncomine™ Comprehensive Panel
Time frame: 1 month / 8 samples
Pathological characterization of lung carcinomas
Histological classification of carcinomas and immunohistochemistry with lineage markers
Time frame: 1 month / 8 samples
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