The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of motor function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through three conditions of transcranial direct current stimulation with for 30 minutes. Three conditions are 1) Dual stimulation 1: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area. 2) Dual stimulation 2: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area. 3) Single stimulation: anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
30
stimulating primary motor cortex with anodal transcranial direct current stimulation
stimulating premotor cortex with anodal transcranial direct current stimulation
stimulating anterior intraparietal sulcus with anodal transcranial direct current stimulation
hand motor task for 30 minutes during transcranial direct current stimulation
Samsung Medical Center
Seoul, South Korea
Changes in motor evoked potentia
measure the motor threshold and amplitude of motor evoked potential in first dorsal interosseous muscle.
Time frame: Baseline and after intervention (approximately 2 weeks)
changes in nine hole peg test
Nine-Hole Peg Test is used to measure finger dexterity in patients with various neurological diagnoses.
Time frame: Baseline and after intervention (approximately 2 weeks)
changes in grip and tip pinch strength test
measure the hand strength (grip and tip pinch)
Time frame: Baseline and after intervention (approximately 2 weeks)
changes in box and block test
box and block test measures unilateral gross manual dexterity
Time frame: Baseline and after intervention (approximately 2 weeks)
Changes in brain activation of resting-state functional MRI
Neuroplasticity measure
Time frame: Baseline and after intervention (approximately 2 weeks)
Changes of Cortical activation
Cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany)
Time frame: Baseline and after intervention (approximately 2 weeks)
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