The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of language and cognitive function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on ipsilesional inferior frontal cortex, ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex. 2) Single stimulation 1: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional inferior frontal cortex; 3) Single stimulation 2: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional supraorbital area.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
30
stimulating inferior frontal cortex with transcranial direct current stimulation for 30 minutes
stimulating dorsolateral prefrontal cortex with transcranial direct current stimulation for 30 minutes
aphasia therapy for 30 minutes during transcranial direct current stimulation
Samsung Medical Center
Seoul, South Korea
Changes in Korean Boston naming test
measures naming ability thorough picture naming test
Time frame: Baseline and after intervention (approximately 2 weeks)
Changes in Korean Western Aphasia Battery
assessment of language function and provide aphasia quotients
Time frame: Baseline and after intervention (approximately 2 weeks)
Digit span test
measures memory span
Time frame: Baseline and after intervention (approximately 2 weeks)
Korea Montreal Cognitive Assessment
measure cognitive function
Time frame: Baseline and after intervention (approximately 2 weeks)
Korean Color Word Stroop test
measures selective attention and executive function
Time frame: Baseline and after intervention (approximately 2 weeks)
Controlled Oral Word Association Test
measure verbal fluency
Time frame: Baseline and after intervention (approximately 2 weeks)
Changes of Cortical activation
Cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany)
Time frame: Baseline and after intervention (approximately 2 weeks)
Changes in brain activation of resting-state and task functional MRI
Neuroplasticity measure
Time frame: Baseline and after intervention (approximately 2 weeks)
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