HP Improves Sleep and Overall Survival Rate in Maintenance Hemodialysis Patients

Shanghai Pudong Hospital156 enrolled

Overview

Sleep disturbance has been long-standing torments in most of patients with maintenance hemodialysis (HD). In this study, we attempted to explore whether long-term hemoperfusion (HP) could improve sleep disorder and increase overall survival rate in HD patients.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

156

Conditions

Hemoperfusion

Interventions

hemoperfusion(HP)DEVICE

These patients were computer-matched into two groups, involving 100 patients with absolute HD vs. 100 cases with HD+HP.HP was performed 1-2 times/per 2 weeks, and each session lasted for two hours.Self-reported sleep disturbance was evaluated before and after observational time (two-year period), which lasted at least 7 hours based on the recommendations presented by National Institute of Health (NIH). Sleep efficiency (%) was calculated as the ratio of sleep duration to total time in bed, and was multiplied by 100.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. duration of maintenance HD should be equal or more than 3 months, 2. patient's age should be equal or more than 18 years Exclusion Criteria: \- i) he/she diagnosed with malignant tumors, an active rheumatism, infectious diseases, or a severe heart failure ii) he/she would disagree with the study 3. he/she has received a short-term poor prognosis 4. he/she would be more than 80 years old

Outcomes

Primary Outcomes

improvement of self-reported sleep disturbance

Analysis of the sleep disturbance by using Pittsburgh Sleep Quality Index (PSQI) questionnaire

Time frame: 2 years

Secondary Outcomes

survival

increase overall survival rate

Time frame: 2 years

Data from ClinicalTrials.gov

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