Medical Abortion With Single Daily Dose of Misoprostol

Phase 3CompletedNCT03487354

Ain Shams University200 enrolled

Overview

Medical abortion using multiple vs single daily dose of misoprostol in first trimester miscarriage.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

200

Conditions

Miscarriage

Interventions

MisoprostolDRUG

Misoprostol

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Maternal age more than 18 years old (age of legal consent). * Gestational age less than 13 weeks. * Hemoglobin \>10 g/dL. * BMI between 25 kg/m2 and 35 kg/m2. * Missed abortion. * Living fetus with multiple congenital malformations incompatible with life. Exclusion Criteria: * Maternal age less than 18 years old. * Gestational age more than 12 weeks. * Hemoglobin \<10 g/dL. * Anencephaly. * Fibroid uterus. * BMI less than 25kg/m2 and more than 35kg/m2. * Coagulopathy. * History or evidence of adrenal pathology. * Previous attempts for induction of abortion in the current pregnancy. * Allergy to misoprostol or letrozole. * Medical disorder that contraindicate induction of abortion (e.g. heart failure).

Locations (1)

Ain Shams University Maternity Hospital

Cairo, Egypt

Outcomes

Primary Outcomes

Complete miscarriage

Assessed by trans-vaginal ultrasound where endometrial thickness less than 15 mm is considered complete miscarriage

Time frame: one week

Data from ClinicalTrials.gov

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